Wednesday, February 22, 2012

In [activity] test tube does not correlate...

How powerful antibiotics lose their kick against viruses, such as vancomycin-resistant enterococci (VRE) and methicillin-resistant staphylococcus gold (MRSA), scientists are looking for new antimicrobial agents from natural sources. Allitsyn, a major component of garlic, is one such agent, and has recently been shown to be powerful against MRSA and VRE in two studies presented at the 41 th conference on antimicrobial agents and chemotherapy in Chicago in December. Research conducted by Jaya Prakash and his colleagues at the National University of Medical Sciences in Lombard, Illinois, found that allicin has strong activity against VRE in vitro. The main problem with VRE that it inhabits the intestines, says Prakash. Many antibiotics are used to control and prevent colonization also affects the normal flora. The ideal solution, she says, would prevent colonization of food substances, taking into account the safety of such compounds on antibiotics. Besides, she adds, the likelihood of resistance development is low. Even a small amount of these substances, they do not become resistant. In his studies, researchers have allitsyn of garlic pills and determine its concentration. During the test tube showed that the number of micrograms was enough to significantly inhibit growth of VRE. In contrast to 4000 g


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allytsyna corresponds to the amount found in one clove of garlic. Up to 25 grams of garlic per day you can eat does not create a risk of toxic side effects. Prakash warns that it's too early to say how much allitsyn consumption will reap the rewards of enteric VRE. In [activity] test tube does not correlate with activity in vivo, prevents it. And the bad news is that allicin is destroyed when garlic, cooked in oil. The next phase of their work, they will study the effects on intestinal microflora allitsyn animals to determine the concentration allitsyn be effective in vivo. In another study, Ron Cutler of the University of East London (UK) and colleagues found that allitsyn liquid and cream formulations were very strong on clinical isolates of MRSA, including resistant mupirocinthe agent commonly used for eradication of MRSA strattera without prescritpion carriage among hospital staff and patients . Current storage allitsyn can be used as a safe, natural alternative to mupirocin to eliminate MRSA carriage and other germs from the nose, skin, wounds and bandages, he said, and they can also be used in the mile and antimicrobials. .

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